Recommended Citation
Han J, Li Y, Liu X, Zhou T, Sun H, Edwards P, Gao H, Yu FS, and Qiao X. Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo PLoS One 2018; 13(3):e0193031.
Document Type
Article
Publication Date
1-1-2018
Publication Title
PLoS One
Abstract
The oral anti-diabetic drug metformin has been found to reduce cardiovascular complications independent of glycemic control in diabetic patients. However, its role in diabetic retinal microvascular complications is not clear. This study is to investigate the effects of metformin on retinal vascular endothelium and its possible mechanisms, regarding two major pathogenic features of diabetic retinopathy: angiogenesis and inflammation. In human retinal vascular endothelial cell culture, metformin inhibited various steps of angiogenesis including endothelial cell proliferation, migration, and tube formation in a dose-dependent manner. Its anti-angiogenic activity was confirmed in vivo that metformin significantly reduced spontaneous intraretinal neovascularization in a very-low-density lipoprotein receptor knockout mutant mouse (pp
Medical Subject Headings
Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial Cells; Humans; Hypoglycemic Agents; Inflammation; Inflammation Mediators; Metformin; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Receptors, LDL; Retina
PubMed ID
29513760
Volume
13
Issue
3
First Page
0193031
Last Page
0193031
