Document Type

Article

Publication Date

1-1-2018

Publication Title

PLoS One

Abstract

The oral anti-diabetic drug metformin has been found to reduce cardiovascular complications independent of glycemic control in diabetic patients. However, its role in diabetic retinal microvascular complications is not clear. This study is to investigate the effects of metformin on retinal vascular endothelium and its possible mechanisms, regarding two major pathogenic features of diabetic retinopathy: angiogenesis and inflammation. In human retinal vascular endothelial cell culture, metformin inhibited various steps of angiogenesis including endothelial cell proliferation, migration, and tube formation in a dose-dependent manner. Its anti-angiogenic activity was confirmed in vivo that metformin significantly reduced spontaneous intraretinal neovascularization in a very-low-density lipoprotein receptor knockout mutant mouse (pp

Medical Subject Headings

Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial Cells; Humans; Hypoglycemic Agents; Inflammation; Inflammation Mediators; Metformin; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Receptors, LDL; Retina

PubMed ID

29513760

Volume

13

Issue

3

First Page

0193031

Last Page

0193031

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