Sinus Pathophysiology of Odontogenic Sinusitis

Authors

John R. Craig, Henry Ford HealthFollow
Claire Hopkins

Recommended Citation

Craig JR, and Hopkins C. Sinus Pathophysiology of Odontogenic Sinusitis. Otolaryngol Clin North Am 2024; 57(6):1007-1018.

Document Type

Article

Publication Date

12-1-2024

Publication Title

Otolaryngologic clinics of North America

Abstract

Odontogenic sinusitis (ODS) is distinct pathophysiologically from nonodontogenic rhinosinusitis. ODS refers to bacterial sinusitis secondary to infectious dental pathology or procedures. Sinus mucosal inflammation in ODS is severe, mostly lymphocytic, and is driven by Th1 or Th17 inflammation. The sinus's respiratory mucosa maintains its structure and function, contrary to significant epithelial barrier dysfunction seen in some forms of chronic rhinosinusitis. The severe inflammation and infection of ODS help explain certain unique clinical features like foul-smelling drainage, frequent purulence, and papillary edema on nasal endoscopy. Appreciating the unique pathophysiology of ODS facilitates its recognition and selection of optimal interventions.

Medical Subject Headings

Humans; Sinusitis; Rhinitis; Endoscopy; Chronic Disease; Paranasal Sinuses

PubMed ID

39428205

Volume

57

Issue

6

First Page

1007

Last Page

1018