Neuropeptide density in anterior and posterior cadaveric nasal mucosa
Recommended Citation
Daklallah M, Goosmann M, Hensley M, Hollemon D, Peri D, Craig J. Neuropeptide density in anterior and posterior cadaveric nasal mucosa. J Allergy Clin Immunol 2026; 157(2):AB250.
Document Type
Conference Proceeding
Publication Date
2-1-2026
Publication Title
J Allergy Clin Immunol
Keywords
calcitonin gene related peptide, choline acetyltransferase, eosin, formaldehyde, hematoxylin, neurokinin, neurokinin B, neuropeptide, neuropeptide Y, substance P, tyrosine 3 monooxygenase, autonomic nerve, cadaver, chronic rhinitis, conference abstract, glandular system, human, human tissue, neurogenic inflammation, nose mucosa, pathophysiology, rhinitis
Abstract
Rationale: Chronic rhinitis may be allergic, nonallergic, or mixed, and causes various nasal symptoms. Neuropeptide release from sensory and autonomic nerves plays a significant role in rhinitis pathophysiology and symptomatology, but has been incompletely studied. This study explored densities of neuropeptides in different regions of cadaveric nasal mucosa. Methods: Full-thickness nasal mucosal specimens were harvested from two regions in 10 fresh cadavers: anterolateral and posterolateral nasal walls (ALNW, PLNW). Specimens were formalin-fixed, sectioned, and stained with hemotoxylin and eosin (H&E) for neuropeptides (substance-P, calcitonin gene-related peptide, neurokinins-A and B (NKA/NKB), vasointestinal peptide, neuropeptide Y), and enzymes choline acetyltransferase (ChAT) and tyrosine hydroxylase (TH). Neuropeptide and enzyme percent areas were compared between markers in each tissue region, and between the tissue regions. Results: Ten cadaveric specimens were analyzed. Mean percent areas of neuropeptides and enzymes ranged from 1-13%, with NKA showing greatest percent area (ALNW 12.8%, PLNW 12.1%), followed by TH (ALNW 12.3%, PLNW 10.4%). NKB and ChAT demonstrated mean percent areas of 7.3-8.6% across regions. While some markers demonstrated percent areas that differed significantly within each tissue region, there were no significant marker differences between the regions. Conclusions: NKA, TH, ChAT and NKB were the most highly expressed neuropeptides and enzymes in cadaveric nasal mucosa, and were distributed similarly between the ALNW and PLNW. Future studies should explore the role these markers play in patients with chronic rhinitis, especially with regard to neurogenic inflammation and glandular hypersecretion. Additionally, whether neurokinins represent a potentially novel therapeutic target should also be studied.
Volume
157
Issue
2
First Page
AB250
