Pleomorphic fibroma of the skin with MDM2 immunoreactivity: A potential diagnostic pitfall

Authors

Mehrnoosh Tashakori, Henry Ford HealthFollow
Jason Pimentel, Henry Ford HealthFollow
Brooke E. Howitt
Jessica Sanchez, Henry Ford HealthFollow
Susan Michalowski, Henry Ford Health
Dhananjay A. Chitale, Henry Ford HealthFollow
Adrian H. Ormsby, Henry Ford HealthFollow
Sean R. Williamson, Henry Ford HealthFollow

Recommended Citation

Tashakori M, Pimentel J, Howitt BE, Sanchez J, Michalowski S, Chitale D, Ormsby AH, and Williamson SR. Pleomorphic fibroma of the skin with MDM2 immunoreactivity: a potential diagnostic pitfall. J Cutan Pathol 2017.

Document Type

Article

Publication Date

1-1-2018

Publication Title

J cutan pathol

Abstract

Pleomorphic fibroma is a rare benign cutaneous neoplasm characterized by spindle-shaped cells and multinucleated giant cells scattered throughout collagenous stroma. These morphologic features can lead to diagnostic confusion, including atypical lipomatous tumor as one consideration. In contrast to atypical lipomatous tumor, previous studies have found pleomorphic fibroma to be negative for MDM2 immunohistochemical staining and MDM2 gene amplification. Here, we present a case of pleomorphic fibroma of skin with nuclear MDM2 immunoreactivity in the absence of MDM2 gene amplification, underscoring the superiority of fluorescence in situ hybridization as a diagnostic test in this differential diagnosis. The RB1 locus is also explored for differential diagnosis with pleomorphic/spindle cell lipoma and related entities.

Medical Subject Headings

Biomarkers, Tumor; Female; Histiocytoma, Benign Fibrous; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lipoma; Proto-Oncogene Proteins c-mdm2; Skin Neoplasms; Young Adult

PubMed ID

28981153

Volume

45

Issue

1

First Page

59

Last Page

62