A Rare Case of Primary Cutaneous Signet-Ring Cell Melanoma With Discrepant Findings on Gene Expression Profiling and Chromosomal Microarray Analysis

Authors

Wyatt Boothby-Shoemaker
Michael Kwa, Henry Ford HealthFollow
Laurie L. Kohen, Henry Ford HealthFollow
Brandon M. Shaw, Henry Ford HealthFollow
Ben J. Friedman, Henry Ford HealthFollow

Recommended Citation

Boothby-Shoemaker W, Kwa M, Kohen L, Shaw B, and Friedman BJ. A Rare Case of Primary Cutaneous Signet-Ring Cell Melanoma With Discrepant Findings on Gene Expression Profiling and Chromosomal Microarray Analysis. Am J Dermatopathol 2022.

Document Type

Article

Publication Date

3-22-2022

Publication Title

The American Journal of dermatopathology

Abstract

ABSTRACT: Melanoma with signet ring cell features is an exceptionally rare variant of primary cutaneous and metastatic melanoma. The molecular mechanisms underlying this unusual cytologic phenotype in malignant melanocytes are largely unknown. In this report, we aim to add to the literature by describing the histomorphological, immunophenotypic, gene expression, and cytogenetic findings in 1 recently encountered case.

PubMed ID

35316818

ePublication

ePub ahead of print