Placental Histopathologic Findings in Fetal Hereditary Pyropoikilocytosis after Undergoing Successful Intrauterine Transfusion

Authors

Anna Dar
Rachel Brancamp, Henry Ford HealthFollow
Garrett S. Booth
Caitlin E. Hughes

Recommended Citation

Dar A, Brancamp R, Booth GS, and Hughes CE. Placental Histopathologic Findings in Fetal Hereditary Pyropoikilocytosis after Undergoing Successful Intrauterine Transfusion. Fetal Pediatr Pathol 2023; 1-3.

Document Type

Article

Publication Date

12-18-2023

Publication Title

Fetal Pediatr Pathol

Abstract

Background: The available literature on intrauterine transfusion focuses largely on its application in fetal alloimmunization rather than hereditary red cell disorders, with limited illustration of its associated histopathologic findings.

Case report: We present the histologic findings in a placenta associated with preterm delivery of an infant with autosomal SPTA1 mutation following multiple intrauterine transfusions, including appropriate villous maturation, subchorionic organizing hematomas, hemosiderin-laden macrophages, and dysmorphic fetal erythrocytes within villous capillaries.

Conclusion: Intrauterine transfusion is associated with placental histologic findings that reflect procedural changes without significant disruption of placental membranes or villous maturation.

PubMed ID

38108326

ePublication

ePub ahead of print

First Page

1

Last Page

3