A rare case of in situ follicular B-cell neoplasm involving sebaceous lymphadenoma

Authors

Ejas Palathingal Bava, Henry Ford HealthFollow
Wamidh L. Alkhoory, Henry Ford HealthFollow
Sharmila Ghosh, Henry Ford HealthFollow

Recommended Citation

Palathingal Bava E, W LA, and S BG. A rare case of in situ follicular B-cell neoplasm involving sebaceous lymphadenoma. J Hematop 2025;18(1):43.

Document Type

Article

Publication Date

9-17-2025

Publication Title

J Hematop

Abstract

In situ follicular neoplasia (ISFN) is characterized by a monoclonal proliferation of BCL2-positive B cells harboring the translocation t(14;18)(q32;q21). These cells are confined to follicle centers and are usually identified incidentally, with a very low risk of progression to follicular lymphoma. Sebaceous lymphadenoma is a rare, benign salivary gland tumor, most commonly arising in the parotid gland, and is histologically defined by solid epithelial nests and cysts with sebaceous differentiation in a hyperplastic lymphoid stroma. We report an unusual case of ISFN arising within a sebaceous lymphadenoma. To the best of our knowledge, this association has not previously been reported.

Medical Subject Headings

Female; Humans; Adenolymphoma; B-Lymphocytes; Lymphoma, Follicular; Sebaceous Gland Neoplasms; Aged

PubMed ID

40960713

Volume

18

Issue

1

First Page

43

Last Page

43