Clinical and laboratory profile of covid-19 patients with available DAT

Document Type

Conference Proceeding

Publication Date

9-19-2021

Publication Title

Transfusion

Abstract

Background/Case Studies: Investigators have reported an increased rate of direct antiglobulin test (DAT) reactivity with subsequent increased RBC transfusion requirements in Covid-19 patients (pts). We investigated this hypothesis by reviewing our experience with Covid-19. Study Design/Methods: This is a retrospective review of COVID-19 pts evaluated for DAT between 03/2020 and 02/2021 at a tertiary-care center. The study was approved by the Institutional Review Board. We included pts evaluated for DAT within 30 days from a positive COVID-19 testing. Analyses were performed using SPSS; a p value of <0.05 was considered significant. Results were presented as median plus range, mean +/-standard deviation (SD), or percentages as indicated. Variables were compared using the independent two-sample Student t-test or Mann-Whitney test for continuous variables, and the Pearson's Chi-square test/Fisher's exact test for categorical variables. Results/Findings: 83 pts were included; 13(15.7%) were DAT-positive. The median age was 67 years (range 21-90); 51(61%) were females. Among the 13 DATpositive pts, 4(31%) tested positive for IgG and C3d, 5 (38%) tested positive for IgG only, and 4(31%) tested positive for C3d only. There was no difference between DATpositive and DAT-negative pts in age, gender, race, comorbid conditions (results not shown), hemoglobin, lactate dehydrogenase (LDH), haptoglobin, total bilirubin, ferritin, C-reactive protein (CRP), D-dimer, RBC transfusion, need for ICU care, duration of hospital stay, or survival. Table 1 compares the characteristics and outcome of pts stratified by DAT testing results. Conclusions: DAT positivity did not correlate with worsening anemia or increased transfusion needs in Covid-19 pts, contrary to what other investigators had demonstrated. We acknowledge the limitations of our study being retrospective with relatively small sample size. Our findings warrant further investigation in larger cohorts.

PubMed ID

Not assigned.

Volume

61

Issue

SUPPL 3

First Page

126A

Last Page

127A

Find It @ Sladen

Share

COinS