Do African American (AA) have more Aggressive Prostate Cancer (PCa) Diagnosed by Multiparametric Magnet Resonance Imaging (mpMRI) Combined with Fusion Biopsy: Our Institutional Experience in a Racially Mixed Population

Document Type

Conference Proceeding

Publication Date

3-19-2022

Publication Title

Mod Pathol

Abstract

Background: Multiparametric magnet resonance imaging (mpMRI) combined with fusion biopsy is a novel approach with the goal of increased accuracy of detection of clinically significant prostate cancer (PCa). The aim of this study is to compare the findings of mpMRI between African Americans (AA) and European Americans (EA) in our institution. Design: All patients who underwent fusion biopsy at our institution between 2015-2021 are included. Pathological findings including tumor grade and tumor size in the lesion of interest (LOI) were collected from our pathology archives. Clinical information including age, mpMRI findings and PSA density were collected from medical records. Statistical analysis was performed using chi square test and T-test. Results: 390 patients were included in our cohort. 279 (71.6%) EA, 82 (21%) AA and 29 (7.4%) were labeled as other races. Median age was 67 (43, 89), median PSA level was 5.8 ng/ml (0.2, 61), median PSA density was 0.12 (0.03, 1.46). Median number of total combined cores was 16 (9, 58). Median number of LOIs biopsied was 1 (1,5). Median number of cores per LOI was 4 (1, 13). Median largest tumor focus in LOI was 6 mm (0.2, 37). There was no significant association between race and the highest Gleason score (GS) or largest tumor focus in the LOI. There was also no significant association between race and PSA density. (table 1) Conclusions: The majority of men who had mpMRI had PCa in their LOIs with 182 (50.4%) showing clinically significant PCa (GS 7 or higher) in their LOIs. Race was not an independent predictor of GS or size in LOI. African American do not have more aggressive prostate cancer diagnosed by mpMRI.

PubMed ID

Not assigned.

Volume

35

Issue

SUPPL 2

First Page

649

Last Page

650

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