Implementation of routine Clostridioides difficile infection (CDI) primary prophylaxis in lung transplant recipients

Document Type

Article

Publication Date

7-21-2023

Publication Title

Clinical transplantation

Abstract

Lung transplant recipients are at an increased risk for Clostridioides difficile infection (CDI), and those who develop CDI post-transplant can have worsened outcomes including graft failure and death. We sought to describe the efficacy and safety of primary CDI prophylaxis with oral vancomycin among 86 adult lung transplant recipients. Overall, we observed a 9.3% (8/86) incidence of CDI among patients receiving prophylaxis, with the majority of infections occurring a median of 25 days after completion of prophylaxis. Furthermore, we observed a 4.7% incidence of VRE infection/colonization. Opportunities exist to optimize the duration of CDI prophylaxis to balance the benefits and risks in lung transplant recipients.

Medical Subject Headings

Clostridioides difficile; Clostridium Infections/epidemiology/prevention & control; Lung Transplantation/adverse effects; Primary Prevention/methods; Humans; Male; Female; Middle Aged; Aged; Retrospective Studies; Vancomycin/administration & dosage; Anti-Bacterial Agents/administration & dosage; Administration; Oral; Incidence; antibiotic prophylaxis; bacterial: Clostridium difficile; infection and infectious agents; lung (allograft) function/dysfunction

PubMed ID

37477286

ePublication

ePub ahead of print

Volume

37

Issue

9

First Page

e15079

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