One Dose, One Opportunity: An Evaluation of one-time Antibiotic Orders in the Emergency Department
Recommended Citation
Bgatto A, Babe M, Greenlee S, Gregor J, Procopio V. One Dose, One Opportunity: An Evaluation of one-time Antibiotic Orders in the Emergency Department. Am J Health Syst Pharm 2025; 82:S1248.
Document Type
Conference Proceeding
Publication Date
1-8-2025
Publication Title
Am J Health Syst Pharm
Abstract
Purpose: One-time dose antibiotic orders are often utilized by emergency department (ED) providers, deferring continuation of therapy decisions to primary care teams. Prolonged ED boarding times and high patient volumes may result in delays in admission and subsequent antibiotic doses, contributing to adverse effects, longer hospital stays, and increased morbidity and mortality. The purpose of this study is to describe the timeliness of subsequent antibiotic administrations occurring in patients initiated on one-time doses in the ED. Methods: This retrospective descriptive study will include 100 patients who received care at 1 of 5 Henry Ford Health hospital-associated EDs. Patients ≥18 years initiated on a one-time dose of intravenous (IV) antibiotic(s) while in the ED and received a second dose of the same IV antibiotic(s) within 36 hours from July 2023 to December 2023 will be included. Patients initiated on oral antibiotics, IV vancomycin or aminoglycosides will be excluded. The following patient characteristics prior to antibiotic initiation will be collected: age, sex, BMI, serum creatinine, white blood cell, temperature, and antibiotic allergy. Additional data will include the IV antibiotics prescribed, the time of order, the time of administration, and the duration of therapy for both the first and second IV antibiotics. The primary endpoint is the number of patients who received second dose antibiotics on time, defined as within 125% of expected dosing interval. The secondary endpoints are to further describe variables amongst those who had delays in therapy, including number of delayed antibiotic doses, order time, shift time, infectious disease consultation, and patient's location. Descriptive statistics will be utilized for data analysis.
Volume
82
First Page
S1248
