You Want a Piece of Me? Evaluating Living Liver Donor Medication Trends After Donation
Recommended Citation
Stratton P, Ali S, Globerman B, Fitzmaurice M, Poparad-Stezar A. You Want a Piece of Me? Evaluating Living Liver Donor Medication Trends After Donation. Am J Health Syst Pharm 2025; 82(Supplement_1):S1486.
Document Type
Conference Proceeding
Publication Date
1-8-2025
Publication Title
Am J Health Syst Pharm
Abstract
Purpose: Post-operative pain management in living liver donors is often underestimated. Current literature found that 31% and 27% of organ donors reported persistent post-surgical pain even after 6 and 12 months, respectively. It is important that living donors return to daily activities with minimal pain to maintain appropriate recovery after donation. This study evaluates post-operative pain management in patients who undergo liver donation for adequate pain management and patient safety. Methods: This IRB-approved retrospective, cross-sectional study will evaluate adult patients who are living liver donors undergoing elective hepatectomy at Henry Ford Hospital from January 1st, 2016, through December 31st, 2023. Patients who are pregnant, breastfeeding, or lost to follow up are excluded from this study. Data will be extracted from the electronic health record and stored in an encrypted, password protected Excel document. The primary endpoint is opioid requirements, measured via morphine milliequivalent during inpatient stay, at discharge, and at 1-month post-hepatectomy. Key secondary endpoints include length of stay, multimodal pain regimens used, average inpatient daily pain scores, bowel regimen at discharge, inpatient acute pain service consult, and opioid-related adverse events. Additionally, pain-related medical visits, readmissions, and additional pain medication requirements after discharge will be assessed. Supplemental data to be collected includes patient demographics, family/social support, prior opioid use, history of opioid use disorder, prior surgical history, opioid allergies, chronic pain history, alcohol/cannabis use, and smoking/tobacco history. Baseline demographics of patients will be characterized using descriptive statistics, continuous variables will be expressed as a median (IQR), and categorical variables will be expressed as proportions. This data will be evaluated to determine opportunities for improved post-operative pain management in patients who undergo living liver donation.
Volume
82
Issue
Supplement_1
First Page
S1486
