Prospective, randomized, blinded, and placebo-controlled study of Cerebrolysin dose-response effects on long-term functional outcomes in a rat model of mild traumatic brain injury

Authors

Yanlu Zhang, Henry Ford HealthFollow
Michael Chopp, Henry Ford HealthFollow
Zheng Gang Zhang, Henry Ford HealthFollow
Yi Zhang, Henry Ford HealthFollow
Li Zhang, Henry Ford HealthFollow
Mei Lu, Henry Ford HealthFollow
Talan Zhang, Henry Ford HealthFollow
Stefan Winter
Hemma BrandstätterFollow
Asim Mahmood, Henry Ford HealthFollow
Ye Xiong, Henry Ford HealthFollow

Recommended Citation

Zhang Y, Chopp M, Gang Zhang Z, Zhang Y, Zhang L, Lu M, Zhang T, Winter S, Brandstätter H, Mahmood A, Xiong Y. Prospective, randomized, blinded, and placebo-controlled study of Cerebrolysin dose-response effects on long-term functional outcomes in a rat model of mild traumatic brain injury. J Neurosurg. 2018 Nov 1;129(5):1295-1304.

Document Type

Article

Publication Date

11-1-2018

Publication Title

Journal of neurosurgery

Abstract

Using a prospective, randomized, blinded, placebo-controlled protocol, the authors demonstrated that Cerebrolysin at doses of 0.8-7.5 ml/kg, administered 4 hours after injury and then once daily for a total of 10 consecutive days, improves long-term functional outcomes in a rat model of mild closed head injury; a 2.5-ml/kg dose was identified as optimal. These findings suggest that Cerebrolysin has the potential to treat mild traumatic brain injury, the incidence of which is high without effective treatments.

PubMed ID

29303438

Volume

129

Issue

5

First Page

1295

Last Page

1304