Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014-2015 and 2015-2016
Recommended Citation
Segaloff HE, Petrie JG, Malosh RE, Cheng CK, McSpadden EJ, Ferdinands JM, Lamerato L, Lauring AS, Monto AS, Martin ET. Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014-2015 and 2015-2016. Epidemiol Infect. 2018 Aug;146(11):1350-1358.
Document Type
Article
Publication Date
8-1-2018
Publication Title
Epidemiology and infection
Abstract
Our objective was to identify predictors of severe acute respiratory infection in hospitalised patients and understand the impact of vaccination and neuraminidase inhibitor administration on severe influenza. We analysed data from a study evaluating influenza vaccine effectiveness in two Michigan hospitals during the 2014-2015 and 2015-2016 influenza seasons. Adults admitted to the hospital with an acute respiratory infection were eligible. Through patient interview and medical record review, we evaluated potential risk factors for severe disease, defined as ICU admission, 30-day readmission, and hospital length of stay (LOS). Two hundred sixteen of 1119 participants had PCR-confirmed influenza. Frailty score, Charlson score and tertile of prior-year healthcare visits were associated with LOS. Charlson score >2 (OR 1.5 (1.0-2.3)) was associated with ICU admission. Highest tertile of prior-year visits (OR 0.3 (0.2-0.7)) was associated with decreased ICU admission. Increasing tertile of visits (OR 1.5 (1.2-1.8)) was associated with 30-day readmission. Frailty and prior-year healthcare visits were associated with 30-day readmission among influenza-positive participants. Neuraminidase inhibitors were associated with decreased LOS among vaccinated participants with influenza A (HR 1.6 (1.0-2.4)). Overall, frailty and lack of prior-year healthcare visits were predictors of disease severity. Neuraminidase inhibitors were associated with reduced severity among vaccine recipients.
Medical Subject Headings
Acute Disease; Adolescent; Adult; Aged; Enzyme Inhibitors; Female; Frailty; Health Status; Humans; Influenza Vaccines; Influenza, Human; Inpatients; Intensive Care Units; Interviews as Topic; Length of Stay; Male; Michigan; Middle Aged; Morbidity; Nasopharynx; Neuraminidase; Patient Readmission; Respiratory Tract Infections; Risk Factors; Severity of Illness Index; Young Adult
PubMed ID
29880077
Volume
146
Issue
11
First Page
1350
Last Page
1358
