Role of Alström syndrome 1 in the regulation of blood pressure and renal function

Document Type

Article

Publication Date

11-2-2018

Publication Title

JCI Insight

Abstract

Elevated blood pressure (BP) and renal dysfunction are complex traits representing major global health problems. Single nucleotide polymorphisms identified by genome-wide association studies have identified the Alström syndrome 1 (ALMS1) gene locus to render susceptibility for renal dysfunction, hypertension, and chronic kidney disease (CKD). Mutations in the ALMS1 gene in humans causes Alström syndrome, characterized by progressive metabolic alterations including hypertension and CKD. Despite compelling genetic evidence, the underlying biological mechanism by which mutations in the ALMS1 gene lead to the above-mentioned pathophysiology is not understood. We modeled this effect in a KO rat model and showed that ALMS1 genetic deletion leads to hypertension. We demonstrate that the link between ALMS1 and hypertension involves the activation of the renal Na+/K+/2Cl- cotransporter NKCC2, mediated by regulation of its endocytosis. Our findings establish a link between the genetic susceptibility to hypertension, CKD, and the expression of ALMS1 through its role in a salt-reabsorbing tubular segment of the kidney. These data point to ALMS1 as a potentially novel gene involved in BP and renal function regulation.

Medical Subject Headings

Alstrom Syndrome; Animals; Endocytosis; Genetic Predisposition to Disease; Genome-Wide Association Study; Hypertension; Male; Models, Animal; Mutation; Polymorphism, Single Nucleotide; Protein Transport; Proteins; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Solute Carrier Family 12, Member 1

PubMed ID

30385718

Volume

3

Issue

21

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