Genetic, Immunologic, and Environmental Basis of Sarcoidosis
Recommended Citation
Moller DR, Rybicki BA, Hamzeh NY, Montgomery CG, Chen ES, Drake W, and Fontenot A. Genetic, immunological and environmental basis of sarcoidosis. Ann Am Thorac Soc 2017.
Document Type
Article
Publication Date
12-1-2017
Publication Title
Ann Am Thorac Soc
Abstract
Sarcoidosis is a multisystem disease with tremendous heterogeneity in disease manifestations, severity, and clinical course that varies among different ethnic and racial groups. To better understand this disease and to improve the outcomes of patients, a National Heart, Lung, and Blood Institute workshop was convened to assess the current state of knowledge, gaps, and research needs across the clinical, genetic, environmental, and immunologic arenas. We also explored to what extent the interplay of the genetic, environmental, and immunologic factors could explain the different phenotypes and outcomes of patients with sarcoidosis, including the chronic phenotypes that have the greatest healthcare burden. The potential use of current genetic, epigenetic, and immunologic tools along with study approaches that integrate environmental exposures and precise clinical phenotyping were also explored. Finally, we made expert panel-based consensus recommendations for research approaches and priorities to improve our understanding of the effect of these factors on the health outcomes in sarcoidosis.
Medical Subject Headings
Biomedical Research; Consensus; Environmental Exposure; Humans; National Heart, Lung, and Blood Institute (U.S.); Phenotype; Risk Factors; Sarcoidosis; United States
PubMed ID
29073364
Volume
14
Issue
Supplement_6
First Page
429
Last Page
429
