Recommended Citation
Lareau CA, Adrianto I, Levin AM, Iannuzzi MC, Rybicki BA, and Montgomery CG. Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients. Ann Clin Transl Neurol 2015; 2(10):972-977.
Document Type
Article
Publication Date
10-1-2015
Publication Title
Ann Clin Transl Neurol
Abstract
Neurosarcoidosis is a clinical subtype of sarcoidosis characterized by the presence of granulomas in the nervous system. Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10(-8), odds ratios = 4.34) within a zinc finger gene, ZNF592, from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis. We validate the association with ZNF592, a gene previously shown to cause cerebellar ataxia, in a cohort of European-Americans with neurosarcoidosis by uncovering low-frequency variants with a similar risk effect size (chr15:85309284, P = 0.0021, odds ratios = 5.36).
PubMed ID
26478897
Volume
2
Issue
10
First Page
972
Last Page
977
