Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
Recommended Citation
Wang A, Shen J, Rodriguez AA, Neslund-Dudas CM, Rybicki BA, et al. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nat Genet 2023; 55(12):2065-2074.
Document Type
Article
Publication Date
12-1-2023
Publication Title
Nature genetics
Abstract
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
Medical Subject Headings
Humans; Male; Black People; Genetic Predisposition to Disease; Genome-Wide Association Study; Hispanic or Latino; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Risk Factors; White People; Asian People
PubMed ID
37945903
Volume
55
Issue
12
First Page
2065
Last Page
2074
