A Prospective Cohort Study of Persistent Endocrine Disrupting Chemicals and Perceived Stress.
Recommended Citation
Schildroth S, Wesselink AK, Bethea TN, Henn BC, Friedman A, Fruh V, Coleman CM, Lovett SM, Vines AI, Sjodin A, Botelho JC, Calafat AM, Wegienka G, Weuve J, Baird DD, and Wise LA. A Prospective Cohort Study of Persistent Endocrine Disrupting Chemicals and Perceived Stress. Am J Epidemiol 2024.
Document Type
Article
Publication Date
5-28-2024
Publication Title
American journal of epidemiology
Abstract
Persistent endocrine disrupting chemicals (EDCs) can dysregulate the stress response. We evaluated associations between persistent EDCs and perceived stress among participants from the Study of Environment, Lifestyle and Fibroids (n=1,394), a prospective cohort study of Black women. Participants completed the Perceived Stress Scale (PSS-4) at baseline, and every 20 months through 60 months (range of scores: 0-16); higher scores indicated higher stress. EDCs, including per- and polyfluoroalkyl substances (PFAS), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides, were quantified in plasma samples at baseline. We fit Bayesian Kernel Machine Regression (BKMR) and linear mixed effects models to estimate associations of EDCs (as a mixture and individually) with PSS-4 scores at baseline and at each follow-up visit, respectively. Increasing percentiles of the mixture were not strongly associated with PSS-4 scores at baseline, and no interactions were observed among EDCs. Several individual EDCs (e.g., PFDA, PCB 118, PBDE 99) were associated with higher PSS-4 scores at baseline or follow-up, while other EDCs (e.g., PCB 138/158) were associated with lower PSS-4 scores at baseline or follow-up. The directionality of associations for individual EDCs was inconsistent across follow-up visits. In conclusion, specific EDCs may be associated with perceived stress in Black women.
PubMed ID
38803157
ePublication
ePub ahead of print
