Epidemiology of Respiratory Syncytial Virus in Adults and Children With Medically Attended Acute Respiratory Illness Over Three Seasons
Recommended Citation
Begley KM, Leis AM, Petrie JG, Truscon R, Johnson E, Lamerato LE, Wei M, Monto AS, and Martin ET. Epidemiology of RSV in Adults and Children with Medically-Attended Acute Respiratory Illness over Three Seasons. Clin Infect Dis 2024.
Document Type
Article
Publication Date
10-15-2024
Publication Title
Clinical infectious diseases
Abstract
BACKGROUND: Data on the true prevalence of respiratory syncytial virus (RSV) among medically attended acute respiratory illnesses (MAARI) has been limited by the lack of regular clinical testing of mild to moderate illnesses. Here we present a prospective evaluation of the epidemiology of RSV-associated MAARI across age groups and multimorbidity status over 3 seasons, which is informative in light of the recommendations for shared decision making for vaccination in older adults.
METHODS: Ambulatory patients ≥6 months of age meeting a common MAARI case definition were prospectively enrolled in the Michigan Ford Influenza Vaccine Effectiveness (MFIVE) study, a subsite of the US Influenza Vaccine Effectiveness Network. All participants were tested by nasal-throat swab for RSV and influenza, including subtype, independently from clinician-directed testing. Participant illness characteristics and calculated multimorbidity-weighted index (MWI) were collected by in-person survey and electronic medical record review.
RESULTS: Over 3 surveillance seasons (fall 2017 to spring 2020), 9.9% (n = 441) of 4442 participants had RSV detected. RSV-associated MAARI was more prevalent than influenza for participants 6 months to 4 years of age. Adults with RSV-MAARI had higher median MWI scores overall compared to influenza-MAARI and controls with neither virus (1.62, 0.40, and 0.64, respectively).
CONCLUSIONS: RSV is a significant, underrecognized cause of MAARI in both children and adults presenting for ambulatory care. Multimorbidity is an important contributor to RSV-associated MAARI in outpatient adults, providing information to support shared clinical decision making for vaccination.
Medical Subject Headings
Humans; Respiratory Syncytial Virus Infections; Male; Adult; Female; Middle Aged; Prospective Studies; Child, Preschool; Aged; Infant; Respiratory Syncytial Virus, Human; Adolescent; Young Adult; Child; Seasons; Prevalence; Respiratory Tract Infections; Influenza, Human; Michigan; Influenza Vaccines; Acute Disease; Aged, 80 and over
PubMed ID
38836601
ePublication
ePub ahead of print
Volume
79
Issue
4
First Page
1039
Last Page
1045
