The epidemiology of dermatofibrosarcoma protuberans incidence, metastasis, and death among various population groups: A Surveillance, Epidemiology, and End Results database analysis
Recommended Citation
Maghfour J, Genelin X, Olson J, Wang A, Schultz L, and Blalock TW. The epidemiology of dermatofibrosarcoma protuberans incidence, metastasis, and death among various population groups: A Surveillance, Epidemiology, and End Results database analysis. J Am Acad Dermatol 2024.
Document Type
Article
Publication Date
11-1-2024
Publication Title
Journal of the American Academy of Dermatology
Abstract
BACKGROUND: Limited information exists regarding the epidemiology, metastasis, and survival of dermatofibrosarcoma protuberans (DFSP).
OBJECTIVE: To measure DFSP incidence and assess metastasis and survival outcomes.
METHODS: Incidence rate, overall and DFSP-specific survival outcomes for primary DFSP tumors contained in the Surveillance, Epidemiology, and End Results (SEER) registry were analyzed via quasi-Poisson regression, Cox, and competing risk analyses.
RESULTS: DFSP incidence rate was 6.25 (95% CI, 5.93-6.57) cases per million person-years with significantly higher incidence observed among Black individuals than White individuals (8.74 vs 4.53). DFSP with larger tumor size (≥3 cm, odds ratio [OR]: 2.24; 95% CI, 1.62-3.12; P < .001) and tumors located on the head and neck (OR: 4.88; 95% CI, 3.31-7.18; P < .001), and genitalia (OR: 3.16; 95% CI, 1.17-8.52; P = .023) were associated with significantly increased risk of metastasis whereas higher socioeconomic status was associated with significantly decreased risk of metastasis. Larger tumor size (≥3 cm), regardless of location, and age (≥60 years) were associated with significantly worse overall and cancer-specific survival.
LIMITATIONS: Retrospective design of SEER.
CONCLUSION: DFSP incidence is 2-fold higher among Black than White individuals. The risk of DFSP metastasis is significantly increased with tumor size ≥3 cm and tumors located on head and neck, and genitalia. Larger tumor size (≥ 3 cm), regardless of location, and age (≥60 years) are the most important prognostic indicators of survival.
Medical Subject Headings
Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Infant; Male; Middle Aged; Young Adult; Dermatofibrosarcoma; Head and Neck Neoplasms; Incidence; Neoplasm Metastasis; SEER Program; Skin Neoplasms; Survival Rate; Tumor Burden; United States; Black or African American; White
PubMed ID
38908718
ePublication
ePub ahead of print
Volume
91
Issue
5
First Page
826
Last Page
833
