Towards robust deep learning-based autosegmentation in MRI-planned gynecological brachytherapy: Importance of scalable development and comprehensive evaluation
Recommended Citation
Oliva PJ, Ghosh S, Huang F, Wiebe E, Cuartero J, Ghosh S, Boulanger P, Yun J, Punithakumar K, and Menon G. Towards robust deep learning-based autosegmentation in MRI-planned gynecological brachytherapy: Importance of scalable development and comprehensive evaluation. Brachytherapy 2026;25(2):361-372.
Document Type
Article
Publication Date
1-1-2026
Publication Title
Brachytherapy
Keywords
Deep Learning, Humans, Brachytherapy, Female, Magnetic Resonance Imaging, Organs at Risk, Uterine Cervical Neoplasms, Radiotherapy Planning, Computer-Assisted, Radiotherapy Dosage, Urinary Bladder
Abstract
PURPOSE: To present comprehensive development and evaluation methodologies for a generalizable deep learning (DL)-driven autocontouring model of standard pelvic organs-at-risk (OARs) in MRI-planned cervical brachytherapy.
MATERIALS AND METHODS: A curated dataset of 200 3D-MRIs (85% training/validation, 15% testing) including multiple applicator types, varying treated anatomies, and manual contours of OARs (bladder, rectum, sigmoid, small bowel) by 3 physicians was utilized to develop an nnU-Net-based autocontouring model. Iterative tuning was conducted to determine the optimal hyperparameters and enhance evaluation metrics. Model performance was assessed using quantitative metrics, like geometric (e.g., Dice Coefficient (DC) and Hausdorff Distance 95th Percentile (HD95)) and dosimetric (dose-volume histograms (DVHs), dose differences (ΔD2cc)), and then correlated with qualitative physician-review (modified Turing and Likert tests).
RESULTS: Geometric metrics were best for bladder (e.g., mean ± SD DC|HD95(mm) 0.93 ± 0.02|2.26 ± 1.07) with greater variability exhibited for small bowel (0.62 ± 0.16|24.90 ± 14.36). Dosimetric comparisons of manual vs predicted contours showed high agreement in DVHs, with mean ΔD2cc < 0.60 Gy EQD2(3) across all OARs. Model performance was consistent, irrespective of applicator type, OAR volume, or contourer. Quantitative scores in support of DLM were not always associated with as favorable qualitative results, yet physician-review showed clinical acceptability (80% for bladder and rectum).
CONCLUSION: The DL-based autocontouring model, trained on a heterogeneous in-house dataset, demonstrates clinical acceptability for OARs as determined by comprehensive evaluation. It also shows promise for translatability to target contouring, and adaptability to other gynecological (noncervix) brachytherapy applications. Differences in qualitative and quantitative results exist; directionality and magnitude should be considered in clinical usability assessments of brachytherapy autocontouring models.
Medical Subject Headings
Deep Learning; Humans; Brachytherapy; Female; Magnetic Resonance Imaging; Organs at Risk; Uterine Cervical Neoplasms; Radiotherapy Planning, Computer-Assisted; Radiotherapy Dosage; Urinary Bladder
PubMed ID
41571559
ePublication
ePub ahead of print
Volume
25
Issue
2
First Page
361
Last Page
372
