High-risk for developing breast cancer: Differences between white and African American women.

Document Type

Conference Proceeding

Publication Date


Publication Title

Ann Surg Oncol


Although African American (AA) women are more likely to die from breast cancer (BrCa) than White Americans (WAs), they are less likely to get the disease. We hypothesized that AAs are also less likely to exhibit a high risk for getting BrCa than WAs. Methods: 4585 women undergoing screening mammograms between May 2017 and August 2018 completed an iPad-based cancer risk assessment (Hughes riskApp). This technology allowed rapid evaluation of demographic, family, and other pertinent risk factors and enabled a comparison of lifetime risks of BrCa between AAs and WAs. Results: Based on the Hughes riskApp, 655/4585 (14.3%) had a >20% lifetime risk of developing BrCa; High risk was identified in 535/3546 (15.1%) of WAs compared to 120/1039 (11.6%) AAs (Chi square 6.018; p=0.014). None of these patients had breast cancer at the time of study. Conclusions: In this single institution study, women who had otherwise not been identified as being at high risk for developing BrCa were identified by the Hughes riskApp to be eligible for more intense imaging and preventive measures, including testing for deleterious gene mutations. AA women were significantly less likely to have a high lifetime risk (>20%) of developing breast cancer than WAs. This new information parallels population statistics that show AAs are less likely to have developed breast cancer than WAs. Both WAs and AAs are likely to benefit from increased imaging with more BrCas potentially diagnosed early.




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