Bronchial thermoplasty: State of the art

Document Type

Article

Publication Date

9-1-2022

Publication Title

Respirology (Carlton, Vic.)

Abstract

Since the publication of a sham-controlled, randomized trial (AIR2) and subsequent marketing approval by the US Food and Drug Administration, we have significantly advanced our understanding of bronchial thermoplasty (BT)'s scientific basis, long-term safety, clinical efficacy and cost-effectiveness. In particular, the last 2 years have witnessed multiple research publications on several of these counts. In this review, we critically appraise our evolving understanding of BT's biologic underpinnings and clinical impact, offer an evidence-based patient workflow guide for the busy pulmonologist and highlight both current challenges as well as potential solutions for the researcher and the clinician.

Medical Subject Headings

Asthma/surgery; Bronchi/surgery; Bronchial Thermoplasty; Cost-Benefit Analysis; Humans; Randomized Controlled Trials as Topic; Treatment Outcome; bronchial thermoplasty; cost-effectiveness; efficacy; mechanism of action; safety; severe asthma

PubMed ID

35692074

ePublication

ePub ahead of print

Volume

27

Issue

9

First Page

720

Last Page

729

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