Recommended Citation
Kim JH, Brown SL, and Gordon MN. Radiation-induced senescence: therapeutic opportunities. Radiat Oncol 2023; 18(1):10.
Document Type
Article
Publication Date
1-13-2023
Publication Title
Radiat Oncol
Abstract
The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient's quality of life. Although cellular senescence is a normal consequence of aging, there is increasing evidence showing that the radiation-induced senescence in both tumor and adjacent normal tissues contributes to tumor recurrence, metastasis, and resistance to therapy, while chronic senescent cells in the normal tissue and organ are a source of many late damaging effects. In this review, we discuss how to identify cellular senescence using various bio-markers and the role of the so-called senescence-associated secretory phenotype characteristics on the pathogenesis of the radiation-induced late effects. We also discuss therapeutic options to eliminate cellular senescence using either senolytics and/or senostatics. Finally, a discussion of cellular reprogramming is presented, another promising avenue to improve the therapeutic gain of radiotherapy.
Medical Subject Headings
Humans; Quality of Life; Cellular Senescence; Neoplasms; Radiation Injuries
PubMed ID
36639774
Volume
18
Issue
1
First Page
10
Last Page
10
