First-degree family history of cancers in patients with stage I endometrial carcinoma. Prevalence and prognostic impact.
Recommended Citation
Yousif A, Mulla ZD, Pudar J, Elshaikh M, Khalil-Moawad R, and Elshaikh MA. First-degree family history of cancers in patients with stage I endometrial carcinoma. Prevalence and prognostic impact. Arch Gynecol Obstet 2024.
Document Type
Article
Publication Date
11-1-2024
Publication Title
Archives of gynecology and obstetrics
Abstract
BACKGROUND: We aimed to study the impact of first-degree family history on patients with endometrial cancer.
METHODS: We conducted a retrospective chart review from January 1990 to June 2016, comparing stage I endometrial cancer patients with and without a sporadic family history of cancers. We collected the patients' demographic information, tumor characteristics, and treatment plans. During the follow-up period, patient information on tumor recurrence and survival was collected. The chi-square test was used to assess the associations between categorical variables. The Cox proportional hazards regression model was used to estimate multivariate-adjusted hazard ratios (95% confidence interval (CI)).
RESULTS: Among the 1737 patients with stage I endometrial cancer, 709 had a positive first-degree family history of cancers and 1028 had negative family history (FH) of cancers. Patients with positive FH were more likely to be older, have stage IB disease, and receive adjuvant radiotherapy; however, the difference was not statistically significant. At 5 years follow up, patients with a positive family history had longer time to recurrence (TTR) than their negative FH counterparts. Maternal family history of cancer was the most common, followed by a sister's history of cancer, paternal history, brother's history, and offspring history of cancer. Breast, endometrial, and colon cancers are the most common cancers among first-degree relatives.
CONCLUSION: Endometrial cancer patients with sporadic first-degree FH of cancers share similar demographics and tumor characteristics compared to their counterpart with slightly increased likelihood to be older, with stage IB disease and have a longer TTR compared to their negative counterpart.
Medical Subject Headings
Humans; Female; Endometrial Neoplasms; Retrospective Studies; Middle Aged; Neoplasm Staging; Aged; Prognosis; Prevalence; Neoplasm Recurrence, Local; Proportional Hazards Models; Adult
PubMed ID
39327297
ePublication
ePub ahead of print
Volume
310
Issue
5
First Page
2595
Last Page
2602
