Executive Summary of the ARS Appropriate Use Criteria for Treatment of Anal Cancer

Document Type

Article

Publication Date

7-6-2019

Publication Title

Int J Radiat Oncol Biol Phys

Abstract

PURPOSE: The American Radium Society Appropriate Use Criteria (ARS AUC) presented in this manuscript are evidence-based guidelines for curative- intent treatment of non-metastatic anal squamous cell cancer that are developed by a multidisciplinary expert panel.

METHODS: Guideline development and systematic review using PRISMA methodology include an extensive analysis of current medical literature from peer-reviewed journals and application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures. In those instances where evidence is not definitive, expert opinion may be used to recommend imaging or treatment.

RESULTS: Evidence-based guidelines are presented about the evaluation and treatment of anal cancer in various clinical scenarios that are derived from supporting literature and multidisciplinary consensus.

CONCLUSIONS: These guidelines are intended for the use of all practitioners and patients who desire information about the management of anal cancer covered in these guidelines.

Medical Subject Headings

Anal Canal/anatomy & histology; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Anus Neoplasms/pathology/therapy; Capecitabine/therapeutic use; Carcinoma; Squamous Cell/pathology/therapy; Chemoradiotherapy/methods; Cisplatin/therapeutic use; Consensus; Delphi Technique; ErbB Receptors/antagonists & inhibitors; Female; Humans; Male; Margins of Excision; Mitomycin/therapeutic use; Precision Medicine; Radiotherapy; Salvage Therapy; Sex Factors; Societies; Medical; Treatment Outcome; United States

PubMed ID

31288054

ePublication

ePub ahead of print

Volume

105

Issue

3

First Page

591

Last Page

605

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