First-degree family history of cancer in women with stage I endometrial carcinoma: Prevalence and prognostic impact

Document Type

Conference Proceeding

Publication Date

11-1-2024

Publication Title

Gynecol Oncol

Keywords

biological marker, adjuvant radiotherapy, adult, cancer patient, cancer recurrence, cohort analysis, colon cancer, conference abstract, controlled study, diagnosis, drug therapy, endometrioid carcinoma, endometrium cancer, endometrium carcinoma, family history, female, first-degree relative, genetic counseling, human, hysterectomy, major clinical study, middle aged, oophorectomy, prevalence, radiotherapy, surgery, uterus cancer

Abstract

Objectives: The significance of a family history of malignancy in endometrial cancer patients has been inconsistently reported in the literature. Most cases of uterine cancer are sporadic; however, familial clustering is observed in around 5 % of cases. In our cohort, we examined the first-degree family history of cancer in women with stage I uterine endometrioid carcinoma. Methods: Our study cohort included 1741 patients. All underwent a hysterectomy and oophorectomy, and they were managed with observation or adjuvant radiotherapy alone; 701 (40 %) patients reported family history (FH) of cancer in their first-degree relatives (FDR), and 1030 reported no or unknown FH of cancer in their FDR. Descriptive statistical analysis was performed to characterize our study cohort. Results: Table 1 shows the total number of patients, 1731, among whom 701 (40 %) reported a positive family history compared to 1030 (60 %) who reported a negative family history of cancers. Both groups had similar age and race distribution. Maternal FH of cancer was reported in 50 % of patients and paternal in 34 %. Breast, colon, and endometrial cancers were most frequently reported in mothers and sisters of endometrial cancer patients, respectively. In contrast, lung, prostate, and colon cancers were the top 3 cancers in endometrial cancer patients' fathers. Cancer recurrence was slightly increased in patients with FH of cancer in their FDR (8 % vs 7 %). Conclusions: First-degree family history of cancer is common in patients with stage I endometrial cancer. Genetic counseling for patients with endometrial cancer should be considered in this population. Further research is needed to elucidate its prognostic role in endometrial cancer patients. [Formula presented]

Volume

190

First Page

S139

Last Page

S140

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