Neuropsychiatric Lupus with Antibody-Mediated Striatal Encephalitis

Authors

Brendan P. Kelley, Henry Ford HealthFollow
John Corrigan, Henry Ford HealthFollow
Suresh C. Patel, Henry Ford HealthFollow
Brent Griffith, Henry Ford HealthFollow

Recommended Citation

Kelley BP, Corrigan JJ, Patel SC, and Griffith BD. Neuropsychiatric lupus with antibody-mediated striatal encephalitis. AJNR Am J Neuroradiol 2018 Dec;39(12):2263-2269.

Document Type

Article

Publication Date

12-1-2018

Publication Title

AJNR. American journal of neuroradiology

Abstract

Systemic lupus erythematosus is a chronic autoimmune disease characterized by the production of autoantibodies resulting in tissue injury across multiple organs; up to 50% of patients develop neurologic involvement, collectively referred to as neuropsychiatric systemic lupus erythematosus. The cases in this clinical report will highlight a subtype of neuropsychiatric systemic lupus erythematosus demonstrating imaging findings of striatal inflammation responsive to plasmapheresis similar to those in the subset of N-methyl-D-aspartate receptor autoimmune encephalitis that involves the striatum. Although the cause for this striking imaging appearance is not definitely known, literature will be presented supporting the hypothesis that it is due to peripheral anti-double-stranded DNA antibodies entering the central nervous system to cross-react with N-methyl-D-aspartate receptor antigens.

PubMed ID

30467216

Volume

39

Issue

12

First Page

2263

Last Page

2269