Seroconversion of SSA and the Development of Inflammatory Myositis in a Patient With Chronic Joint Pain: A Potential Overlap Connective Tissue Disease
Recommended Citation
Maraj D, El-Feki I, and Zebda H. Seroconversion of SSA and the Development of Inflammatory Myositis in a Patient With Chronic Joint Pain: A Potential Overlap Connective Tissue Disease. Cureus 2025;17(9):e91619.
Document Type
Article
Publication Date
9-1-2025
Publication Title
Cureus
Keywords
anti-ssa; connective tissue disease; inflammatory myositis; mixed connective tissue disease; myositis
Abstract
We present the case of a 48-year-old female with a complex medical history, including chronic joint pain on methadone and chronic obstructive pulmonary disease (COPD), who developed right forearm myositis following a series of orthopedic procedures and infections. Initially thought to be infectious in origin, subsequent investigations revealed chronic inflammation without infection. The patient's serologic profile evolved over time, with new-onset SSA antibody positivity, positive antinuclear antibody (ANA) and rheumatoid factor (RF), and concern for overlapping connective tissue disease. This case highlights the diagnostic complexity and evolving nature of autoimmune conditions, particularly in patients with non-specific musculoskeletal symptoms and comorbidities.
PubMed ID
41058845
Volume
17
Issue
9
First Page
91619
Last Page
91619
