Title

Sleep and alertness disturbance and substance use disorders: A bi-directional relation

Document Type

Article

Publication Date

4-1-2021

Publication Title

Pharmacology, biochemistry, and behavior

Abstract

The majority of the literature describing the relation of sleep/alertness disturbance and substance use disorders (SUD) has focused on the disruptive effects of substances with abuse liability on sleep and alertness. Rarely have studies or literature reviews assessed or discussed how sleep/alertness disturbance affects substance use. This paper focuses on the sleep/alertness disturbance side of the relation. We argue that the relation is bi-directional and review evidence showing that sleep/alertness disturbance affects all phases of the addiction cycle, including the initiation, maintenance and relapse of SUD. We review a variety of substances across all phases of the addiction cycle and conclude sleep/alertness disturbance is a critical factor in both understanding and treating SUD.

PubMed ID

33582097

Volume

203

Find It @ Sladen

Share

COinS