Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions
Recommended Citation
Aggarwal B, Gao Y, Alfini A, Azarbarzin A, Anafi RC, Glazer Baron K, Bautch VL, Bowles N, Broussard JL, Brown M, Cheng P, Cook SH, Cortese R, Fernandez FX, Galis Z, Johnson DA, Jelic S, Lipton JO, Lutsey PL, Miao Q, Ordovas JM, Prather AA, Swirski FK, Tasali E, Vargas I, Grandner MA, and Lloyd-Jones D. Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions. Nat Rev Cardiol 2025.
Document Type
Article
Publication Date
9-18-2025
Publication Title
Nat Rev Cardiol
Abstract
The interaction between sleep, circadian rhythms and cardiovascular resilience is a crucial yet underexplored research area with important public health implications. Disruptions in sleep and circadian rhythms exacerbate hypertension, diabetes mellitus and obesity, conditions that are increasingly prevalent globally and increase the risk of cardiovascular disease. A National Heart, Lung, and Blood Institute workshop examined these connections, as well as the emerging concept of cardiovascular resilience as a dynamic and multifaceted concept spanning molecular, cellular and systemic levels across an individual's lifespan. The workshop emphasized the need to expand the focus from solely understanding whether and how sleep and circadian rhythm disturbances contribute to disease, to also exploring how healthy sleep and aligned circadian rhythms can increase cardiovascular resilience. To develop a Roadmap towards this goal, workshop participants identified key knowledge gaps and research opportunities, including the need to integrate biological, behavioural, environmental and societal factors in sleep and circadian health with cardiovascular research to identify therapeutic targets. Proposed interventions encompass behavioural therapies, chronotherapy, lifestyle changes, organizational policies and public health initiatives aimed at improving sleep and circadian health for better cardiovascular outcomes. Future cross-disciplinary research and translation of discoveries into public health strategies and clinical practices could improve cardiovascular resilience across the lifespan in all populations.
PubMed ID
40968347
ePublication
ePub ahead of print
