Impact of Sleep Disorders on Quality of Life and Disease Control in Chronic Urticaria Patients: A Cross-Sectional Analysis
Recommended Citation
Ojeda IC, Al-Nesf MA, Ibrahim T, Thalapp SR, Ensina LF, Lacerda A, Criado R, Muñoz N, Muñoz D, Muñoz J, Kasperska-Zajac A, Zalewska-Janowska A, Krasowska D, Bartosiński J, Kolacinska-Flont M, Kupryś-Lipińska I, Kurowski M, Tomaszewska K, Brzoza ZK, Fomina D, Strelyaev N, Anastasiia AA, Allenov A, Danilycheva I, Latysheva E, Meshkova R, Gimenez-Arnau A, Pesqué D, Kulthanan K, Viriyaskultorn N. Impact of Sleep Disorders on Quality of Life and Disease Control in Chronic Urticaria Patients: A Cross-Sectional Analysis. J Allergy Clin Immunol 2025; 155(2):1.
Document Type
Conference Proceeding
Publication Date
2-1-2025
Publication Title
J Allergy Clin Immunol
Abstract
Rationale Chronic urticaria (CU) significantly impacts patients' quality of life (QoL), particularly when compounded by sleep disorders such as insomnia, obstructive sleep apnea (OSA), and restless legs syndrome (RLS). This study aims to evaluate the prevalence of these sleep disorders in patients with CU and to assess their association with disease control and quality of life impairment. Methods A total of 1,460 CU patients were assessed using the CU-Q2oL and the Urticaria Control Test (UCT). Sleep disorders were evaluated using the General Sleep Assessment Questionnaire (GSAQ), which identified the presence of insomnia, OSA, and RLS. Descriptive analyses categorized patients based on the impact of CU on their QoL (moderate vs. severe) and disease control (controlled vs. uncontrolled). Logistic regression models were employed to examine the role of sleep disorders as predictors of QoL impact and disease control. Results Insomnia, OSA, and RLS were significantly more prevalent in patients with severe QoL impairment (64.1%, 55.6%, and 25.1%, respectively) and in those with uncontrolled CU (44.1%, 41.1%, and 15.4%, respectively) compared to their counterparts. Regression analyses demonstrated that insomnia (OR: 4.836, p<0.001), OSA (OR: 3.022, p<0.001), and RLS (OR: 3.150, p<0.001) were strong predictors of poor QoL. Similarly, these sleep disorders were significantly associated with uncontrolled CU. Conclusions Sleep disorders, particularly insomnia, OSA, and RLS, are prevalent among CU patients and are significant predictors of poor QoL and uncontrolled disease. Addressing sleep disorders in CU patients could improve both disease management and patient well-being.
Volume
155
Issue
2
First Page
1
