Comparison of the paroxetine's effect on the sleep parameters measurements extracted by polysomnography vs somno-art in depressed patients
Recommended Citation
Viola A, Thiesse L, Staner L, Fuchs G, Kirscher D, Roth T, Schaffhauser JY, Saoud J, Luthringer R. Comparison of the paroxetine's effect on the sleep parameters measurements extracted by polysomnography vs somno-art in depressed patients. J Sleep Res 2022; 31.
Document Type
Conference Proceeding
Publication Date
10-20-2022
Publication Title
J Sleep Res
Abstract
Introduction: Sleep dysfunction, manifesting as too much or too little sleep, can be an indicator of depression. In addition, sleep dysfunction can be a side effect of antidepressant medications. It has been clearly shown that depression is associated with abnormal sleep architecture and the treatment by antidepressants such as selective serotonin reuptake inhibitors (SSRIs) are associated with sleep parameters modulations. The Somno-Art solution, a new sleep scoring approach, has been validated in various studies including healthy subjects and pathological patients. This novel technology can be a valid alternative to the cumbersome PSG recordings for the sleep parameters measurement. Objectives: The aim of the current analysis was to show that the sleep stage scoring extracted by the Somno-Art solution compares favorably to PSG and can be used in pharmaceutical trials to estimate paroxetine's effect in depressed patients. Methods: One baseline night followed by a second night after a dose of paroxetine were recorded from 11 depressed patients. Sleep staging was obtained from PSG and from Somno-Art analysis on synchronized electrocardiogram and actimetry signals. For each sleep parameter investigated, Wilcoxon signed-rank test between baseline night and night under paroxetine was performed. Statistical significance was set at p < 0.05. Results: Both PSG and Somno-Art analyses show a significant increase on NREM sleep and significant decrease on REM sleep. No other sleep parameters show significant variation, but we can see that the trends shown on the PSG are similar on the Somno-Art analyses. Conclusions: Similar to PSG, Somno-Art shows comparable differences on the sleep parameters, and allows for the same conclusions to be drawn regarding the potential drug effect. Somno-Art offers a reliable solution for sleep parameters evaluations.
Volume
31
