Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients

Document Type

Article

Publication Date

4-25-2019

Publication Title

The breast journal

Keywords

Adult, Black or African American/genetics, Aged, Aged, 80 and over, Breast Neoplasms/genetics/pathology/therapy, Female, Gene Expression Regulation, Neoplastic, Humans, Middle Aged, Neoplasm Recurrence, Local/genetics/pathology, Prognosis, Receptor, ErbB-2/metabolism, Transcriptome, White People/genetics, Oncotype DX, breast cancer, disparities

Abstract

We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS ( ≥ 31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.

Medical Subject Headings

Adult; Black or African American/genetics; Aged; Aged; 80 and over; Breast Neoplasms/genetics/pathology/therapy; Female; Gene Expression Regulation; Neoplastic; Humans; Middle Aged; Neoplasm Recurrence; Local/genetics/pathology; Prognosis; Receptor; ErbB-2/metabolism; Transcriptome; White People/genetics; Oncotype DX; breast cancer; disparities

PubMed ID

31025467

ePublication

ePub ahead of print

Volume

25

Issue

4

First Page

667

Last Page

671

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