Severe phlebitis-like abnormal reaction following great saphenous vein cyanoacrylate closure

Document Type

Article

Publication Date

7-1-2019

Publication Title

J Vasc Surg Venous Lymphat Disord

Abstract

The VenaSeal closure system is a nonthermal, nontumescent technique that was approved by the U.S. Food and Drug Administration in 2015 for the treatment of superficial venous insufficiency. Studies have demonstrated a comparable efficacy and safety profile to thermal ablation procedures. We report a case of a middle-aged woman who developed a severe, prolonged phlebitis-like reaction requiring treatment with steroids and antihistamines after cyanoacrylate adhesive embolization. This adverse reaction is uncommon but usually self-limiting and is believed to be a type IV hypersensitivity reaction to the cyanoacrylate compound. Knowledge of this potential complication and its treatment are key, because the reaction may be severe with significant morbidity.

Medical Subject Headings

Aged; Cyanoacrylates/adverse effects; Drug Hypersensitivity/diagnosis/drug therapy/etiology; Embolization; Therapeutic/adverse effects; Female; Histamine Antagonists/therapeutic use; Humans; Phlebitis/chemically induced/diagnosis/drug therapy; Saphenous Vein/diagnostic imaging/drug effects; Severity of Illness Index; Steroids/therapeutic use; Treatment Outcome; Varicose Veins/diagnostic imaging/therapy; Venous Insufficiency/diagnostic imaging/therapy; Allergic reaction; Cyanoacrylate embolization; Phlebitis; Venous insufficiency

PubMed ID

31078516

Volume

7

Issue

4

First Page

578

Last Page

582

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