Validation of the Society for Vascular Surgery Appropriate Use Criteria for management of intermittent claudication
Recommended Citation
Vega AA, Mavilian C, Alabi O, Arya S, Brooke BS, Chester C, Conte MS, George EL, Fei K, Fereydooni A, Iannuzzi JC, Kabbani LS, Koleilat I, Lee MH, Malik A, Mize BM, Nguyen TM, Sari Z, Tiu MD, Woo K, O'Banion LA. Validation of the Society for Vascular Surgery Appropriate Use Criteria for Management of Intermittent Claudication. J Vasc Surg. 2026.
Document Type
Article
Publication Date
2-3-2026
Publication Title
Journal of vascular surgery
Keywords
Appropriate use criteria; Appropriateness; Claudication; Intermittent claudication; Peripheral artery disease
Abstract
OBJECTIVE: The aim of this study was to perform a multi-institutional retrospective validation of the Society for Vascular Surgery Appropriate Use Criteria (AUC) for management of intermittent claudication (IC).
METHODS: A retrospective review of patients treated for IC from 2005 to 2024 was performed across seven institutions. Inclusion criteria followed AUC assumptions. All treated limbs were rated as appropriate (benefit outweighs risk [B>R]), indeterminate (IND) or inappropriate (R>B) per the original AUC by two authors, who resolved discrepancies through discussion. Analysis was performed on the patient level. If one limb was rated as R>B, the patient was rated as R>B. For the purposes of comparison, B>R and IND were grouped together (B>R/IND).
RESULTS: A total of 372 patients were included. The median follow-up was 1190 days (interquartile range, 433-2115 days). Treatment was classified as B>R/IND in 245 patients (66%) and R>B in 127 (34%). More patients in the R>B group identified as Black (12.7% vs 6.7%) and Hispanic (19.8% vs 9.2%) (P = .006). Fewer patients in the R>B group were on optimal medical therapy at the time of evaluation (58.3% vs 75.9%; P < .01). More patients in R>B had mild or moderate lifestyle limitations (93.7% vs 68.6%; P < .01) and fewer patients in R>B had exercise therapy prior to revascularization (22% vs 54%; P < .01). The most affected segments were aortoiliac (30.9%) and femoropopliteal (49.7%). Revascularization was performed in 231 patients (104 B>R/IND and 127 R>B). Of the patients who underwent revascularization, 149 underwent unilateral revascularization, and 82 underwent bilateral revascularization. Interventions were most often performed in the femoropopliteal (48.1%) and aortoiliac (35.1%) segments. At 2 years from initial consultation with the vascular surgeon, 19% in the R>B group were free from revascularization compared with 57% in the B>R/IND group (P < .01). Freedom from symptom recurrence at 2 years was lower in the R>B group but did not reach statistical significance (48.9% vs 60%; P = .07). Freedom from reintervention at 2 years following revascularization was significantly lower in the R>B group (64% vs 84%; P = .01). A total of 10 major amputations and 11 minor amputations occurred in 17 patients (4.6%) over the study period. Among patients who had mild/moderate lifestyle limitations and were classified as R>B, 15 (11.8%) underwent nine minor amputations and 10 major amputations. Among patients who had mild or moderate lifestyle limitations and were classified as B>R/IND, no patients underwent any type of amputation.
CONCLUSIONS: In this retrospective multi-institutional cohort, patients with IC who were treated inappropriately (R>B) per the Society for Vascular Surgery AUC experienced significantly worse outcomes compared with those who received appropriate/indeterminate (B>R/IND) treatment.
PubMed ID
41644017
ePublication
ePub ahead of print
