Intraductal papillary mucinous neoplasm with pseudomyxoma peritonei: a case report

Document Type

Article

Publication Date

3-1-2026

Publication Title

Int J Surg Case Rep

Keywords

case report; cytoreduction surgical procedures; hyperthermic intraperitoneal chemotherapy; pancreatic intraductal neoplasms; pseudomyxoma peritonei

Abstract

INTRODUCTION: Pseudomyxoma peritonei (PMP) secondary to pancreatic intraductal papillary mucinous neoplasms (IPMNs) is extremely rare, making diagnosis and treatment of this condition challenging.

CASE PRESENTATION: We present a case of a 67-year-old gentleman diagnosed with a malignant degeneration of IPMN, treated with neoadjuvant systemic therapy, followed by total pancreatectomy. Twelve months after his surgery, he was found to have two capsular hepatic lesions on surveillance imaging. Biopsy confirmed pseudomyxoma peritonei, and the patient subsequently underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).

DISCUSSION: This unique case highlights the importance of post-operative surveillance for surgically resected IPMNs and understanding the role for CRS and HIPEC as an option for treating PMP secondary to IPMNs.

CONCLUSION: Although PMP secondary to IPMN is extremely uncommon, it can occur months to years after initial surgery, and for patients in whom complete cytoreduction is achievable, CRS and HIPEC may represent a viable treatment option.

PubMed ID

41836973

Volume

138

Issue

3

First Page

430

Last Page

437

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