Early Experience of Normothermic Liver Perfusion Pump in Liver Transplantation
Recommended Citation
Chau L, MacLean EK, Kathawate RG, Abdallah Y, Wickramaratne N, Kitajima T, Miyake K, Nagai S, Yoshida A, Abouljoud M, Rizzari M. Early Experience of Normothermic Liver Perfusion Pump in Liver Transplantation. Am J Transplant 2023; 23(6):S721.
Document Type
Conference Proceeding
Publication Date
6-1-2023
Publication Title
Am J Transplant
Abstract
Purpose: Normothermic machine-based liver perfusion (NMP) has demonstrated improved outcomes versus cold ischemic storage in liver-alone transplantation. Methods: This study includes adult liver-alone transplantation recipients at our center from 1/16/2016 to 7/1/2022. Liver transplantation delivered on pump were identified with retrospective chart review. 1-to-2 propensity score matched models adjusting for donor and recipient characteristics were fitted to estimate the treatment effect of NMP on post-reperfusion syndrome, index hospital length of stay (LOS), 3-month biliary complications, biopsy proven rejection, graft survival, and patient survival compared to conventional ischemic cold storage. Results: 593 liver transplantations were included with 42 delivered on NMP. The NMP group had higher DCD liver transplantation (35.7% vs 17.4%, P=0.001), fewer reoperations (9.1% vs. 19.2%, P=0.04), trend towards shorter LOS (9 [IQR: 7-16] vs 10 [IQR:7-18] days, P=0.42), trend towards less post-reperfusion syndrome (11.3% vs 20%, P=0.06). On propensity score matched analysis, OCS livers had non-inferior 3-month biliary complications (HR = 1.34, P = 0.78, [95% C.I. = 0.47-2.78]), biopsy proven rejection (HR = 1.58, P = 0.77, [95% C.I. = 0.49-5.15]), graft failure (HR = 0.42, P = 0.78, [95% C.I. = 0.56-2.62]), and patient death (HR = 0.39, P = 0.66, [95% C.I. = 0.30-2.81]). Conclusions: The use of NMP in liver-alone transplantation in our center is associated with significantly higher proportion of DCD liver transplantation and fewer reoperations, trend towards shorter LOS and post-reperfusion syndrome, as well as non-inferior 3-month biliary complications, graft survival, and patient survival compared to livers delivered on conventional cold ischemic storage. CITATION INFORMATION: Chau L., MacLean E., Kathawate R., Abdallah Y., Wickramaratne N., Kitajima T., Miyake K., Nagai S., Yoshida A., Abouljoud M., Rizzari M. Early Experience of Normothermic Liver Perfusion Pump in Liver Transplantation AJT, Volume 23, Issue 6, Supplement 1. DISCLOSURES: L.Chau: None. M.Abouljoud: None. M.Rizzari: None. E.K.Maclean: n/a. R.G.Kathawate: n/a. Y.Abdallah: n/a. N.Wickramaratne: n/a. T.Kitajima: n/a. K.Miyake: None. S.Nagai: None. A.Yoshida: n/a. [Figure presented]
Volume
23
Issue
6
First Page
S721
