The 24-Hour Normothermic Machine Perfusion of Discarded Human Liver Grafts
Recommended Citation
Shamaa TM, Mohamed A, Bajjoka IE, Crombez C, Nagai S, Yoshida A, Abouljoud M, Rizzari M. The 24-Hour Normothermic Machine Perfusion of Discarded Human Liver Grafts. Am J Transplant 2023; 23(6):S920-S921.
Document Type
Conference Proceeding
Publication Date
6-1-2023
Publication Title
Am J Transplant
Abstract
Purpose: The persistent shortage of liver allografts contributes to significant waitlist mortality. Normothermic machine perfusion (NMP) has the potential to extend viability and allow liver function evaluation in discarded organs. The main aim of the study was to evaluate the recovery of non-usable human livers utilizing NMP. Methods: 6 high-risk human liver grafts that were discarded underwent normothermic liver preservation for an extended period of 24 hours. Transmedics Organ Care System™ liver perfusion device was used to preserve a donor liver in a functioning, near physiologic state. Parameters of biochemical and synthetic liver function were collected periodically and subsequently analyzed. Liver parenchyma and bile duct biopsies were obtained pre- and 24 hours post-NMP. Results: 4/6 (67%) grafts were DCDs with a median age of 54 (IQR: 42-61) years and a median CIT of 262 (IQR: 209-1024) minutes [Table 1]. 5/6 (83%) livers produced a median of 75 ml of bile (Range 55-100) after 24 hrs of NMP. Lactate dropped to normal levels (<2 mmol/L) for all livers after around 4 hrs on NMP [Figure 1]. There was a positive correlation between the 24 hr ALT level and pre-NMP CIT (r=0.9; p=0.02). Biopsies showed improvement of liver architecture with reduced inflammation for 2/6 (33%) at the end of the perfusion Conclusions: Using NMP for discarded liver grafts might identify certain grafts that are suitable for transplantation. Further studies utilizing NMP with subsequent transplantation would validate this strategy. CITATION INFORMATION: Shamaa T., Mohamed A., Bajjoka I., Crombez C., Nagai S., Yoshida A., Abouljoud M., Rizzari M. The 24-Hour Normothermic Machine Perfusion of Discarded Human Liver Grafts AJT, Volume 23, Issue 6, Supplement 1. DISCLOSURES: T.M.Shamaa: None. A.Mohamed: n/a. I.Bajjoka: n/a. C.Crombez: n/a. S.Nagai: None. A.Yoshida: n/a. M.Abouljoud: None. M.Rizzari: None. [Figure presented]
Volume
23
Issue
6
First Page
S920
Last Page
S921
