Asian Americans and prostate cancer: A nationwide population-based analysis
Recommended Citation
Chao GF, Krishna N, Aizer AA, Dalela D, Hanske J, Li H, Meyer CP, Kim SP, Mahal BA, Reznor G, Schmid M, Choueiri TK, Nguyen PL, M OL, and Trinh QD. Asian Americans and prostate cancer: A nationwide population-based analysis. Urol Oncol 2016; 34(5):233.e237-233.e215.
Document Type
Article
Publication Date
5-1-2016
Publication Title
Urologic oncology
Abstract
INTRODUCTION: It remains largely unknown if there are racial disparities in outcomes of prostate cancer (PCa) for Asian American and Pacific Islanders (PIs) (AAPIs). We examined differences in diagnosis, management, and survival of AAPI ethnic groups, relative to their non-Hispanic White (NHW) counterparts.
METHODS: Patients (n = 891,100) with PCa diagnosed between 1988 and 2010 within the surveillance, epidemiology, and end results database were extracted and stratified by ethnic group: Chinese, Japanese, Filipino, Hawaiian, Korean, Vietnamese, Asian Indian/Pakistani, PI, and Other Asian. The effect of ethnic group on stage at presentation, rates of definitive treatment, and PCa-specific mortality was assessed. The severity at diagnosis was defined as: localized (TxN0M0), regional (TxN1M0), or metastatic (TxNxM1).
RESULTS: Relative to NHWs, Asian Indian/Pakistani, Filipino, Hawaiian, and PI men had significantly worse outcomes. Filipino (odds ratio [OR] = 1.38, 95% CI: 1.27-1.51), Hawaiian, (OR = 1.70, 95% CI: 1.41-2.04), Asian Indian/Pakistani (OR = 1.37, 95% CI: 1.15-1.64), and PI men (OR = 1.90, 95% CI: 1.46-2.49) were more likely to present with metastatic PCa (P<0.001). In patients with localized PCa, Filipino men were less likely to receive definitive treatment (OR = 0.91; 95% CI: 0.84-0.97; P = 0.005). Most AAPI groups had lower rates of PCa death except for Hawaiian (hazard ratio = 1.52; 95% CI: 1.30-1.77; P<0.0001) and PI men (hazard ratio = 1.43; 95% CI: 1.12-1.82; P<0.0001).
CONCLUSIONS: Compared with NHWs, AAPI groups were more likely to present with advanced PCa but had better cancer-specific survival. Conversely, Hawaiian and PI men were at greater risk for PCa-specific mortality. Given the different cancer profiles, our results show that there is a need for disaggregation of AAPI data.
Medical Subject Headings
Aged; Asian/statistics & numerical data; China/ethnology; Humans; Japan/ethnology; Korea/ethnology; Logistic Models; Male; Middle Aged; Multivariate Analysis; Outcome Assessment; Health Care/methods/statistics & numerical data; Philippines/ethnology; Prostatic Neoplasms/diagnosis/ethnology/therapy; SEER Program/statistics & numerical data; Severity of Illness Index; Socioeconomic Factors; Survival Analysis; United States; Vietnam/ethnology; Outcomes; Prostate cancer; Racial disparities; Seer
PubMed ID
26725248
Volume
34
Issue
5
First Page
233.e7
Last Page
233.e15
