Quality of life outcomes in peri-urethral calcium hydroxylapatite injection.
Recommended Citation
Griffin MA, Janosek-Albright KJ, Diaz-Insua M, Elshatanoufy S, and Atiemo HO. Quality of life outcomes in peri-urethral calcium hydroxylapatite injection. Int Urogynecol J 2016; 27(12):1879-1887.
Document Type
Article
Publication Date
12-1-2016
Publication Title
Int Urogynecol J
Abstract
INTRODUCTION AND HYPOTHESIS: Peri-urethral calcium hydroxylapatite injection is an established treatment for patients with stress urinary incontinence. Information is limited regarding calcium hydroxylapatite treatment and quality of life (QOL) outcomes. We hypothesize that patients might improve QOL after peri-urethral calcium hydroxylapatite injection, which was reflected in validated questionnaires.
METHODS: The peri-urethral calcium hydroxylapatite injection billing code was used to identify patients who underwent injection from 2011-2013. Female patients who completed the American Urological Association Symptom Score (AUASS), the AUASS QOL and Michigan Incontinence Symptom Index (M-ISI), and the bother score (M-ISI bother), or pad count at baseline and follow-up were included. Change in questionnaire scores and pads were assessed using the paired t test.
RESULTS: Sixty patients underwent 1 (30), 2 (63) or 3 (7 %) peri-urethral calcium hydroxylapatite injections performed by a single surgeon. Thirty-seven patients provided questionnaires and 38 provided pad counts, all with a mean age of 75 years. The overall AUASS, AUASS QOL, and overall M-ISI scores improved in 67.6, 54.8, and 61.3 % respectively (4.5 ± 7.9, 1.3 ± 1.7 and 5.5 ± 8.6 respectively). The M-ISI bother score improved in 44.8 % with a mean improvement of 0.5 ± 2.9, but did not reach significance. There was a 1.7 ± 3.7 decrease in the mean number of pads used daily after the procedure (p = 0.006) and 19 % experienced transient urinary retention.
CONCLUSIONS: Peri-urethral calcium hydroxylapatite injections can improve urinary QOL scores in patients with initial and recurrent stress urinary incontinence. This short-term retrospective analysis suggests that larger long-term studies focusing on QOL outcomes are needed to evaluate the effect of peri-urethral calcium hydroxylapatite has on incontinence-specific QOL.
Medical Subject Headings
Adult; Aged; Aged, 80 and over; Durapatite; Female; Humans; Middle Aged; Quality of Life; Retrospective Studies; Treatment Outcome; Urinary Incontinence, Stress
PubMed ID
27250833
Volume
27
Issue
12
First Page
1879
Last Page
1887
