Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer.
Recommended Citation
Colicchia M, Sharma V, Abdollah F, Briganti A, and Jeffrey Karnes R. Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer. Curr Urol Rep 2017; 18(7):51.
Document Type
Article
Publication Date
7-1-2017
Publication Title
Current urology reports
Abstract
Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates. The therapeutic role of ePLND remains uncertain. While recent retrospective studies suggest an increased number of nodes removed within the ePLND template are associated with improved survival outcomes, such retrospective studies cannot completely adjust for the Will Rodgers phenomenon or surgeon-specific factors. Thus, the results of randomized trials are eagerly awaited in this arena.
Medical Subject Headings
Humans; Lymph Node Excision; Lymphatic Metastasis; Lymphedema; Lymphocele; Male; Pelvis; Postoperative Complications; Prognosis; Prostatectomy; Prostatic Neoplasms; Risk
PubMed ID
28589397
Volume
18
Issue
7
First Page
51
Last Page
51
