Pharmacological Therapies for Male Infertility
Recommended Citation
Rambhatla A, Shah R, Pinggera GM, Mostafa T, Atmoko W, Saleh R, Chung E, Hamoda T, Cayan S, Jun Park H, Kadioglu A, Hubbard L, and Agarwal A. Pharmacological therapies for male infertility. Pharmacol Rev 2024.
Document Type
Article
Publication Date
10-21-2024
Publication Title
Pharmacological reviews
Abstract
Male factor infertility is a multifaceted problem that affects approximately 50% of couples suffering from infertility. Causes of male infertility include endocrine disturbances, gonadotoxins, genetic abnormalities, varicocele, malignancies, infections, congenital or acquired urogenital abnormalities, iatrogenic factors, immunological factors, and idiopathic reasons. There are a variety of treatment options for male infertility, depending on the underlying cause(s). These can include surgical treatments, medical/hormonal therapies, and assisted reproductive techniques (ART), which can be combined with surgical sperm retrieval (SSR) if necessary. In this review article, the pharmacological therapies for male infertility are grouped by their underlying causes. Some of these therapies are targeted and specific, while others are used empirically to treat idiopathic male infertility. This will include treatments to optimize infertility in patients who have hypogonadism, ejaculatory dysfunction, infections, or idiopathic male infertility. Finally, we will provide an overview of the future directions of pharmacological therapies for male infertility.
PubMed ID
39433442
ePublication
ePub ahead of print
