ASSOCIATION BETWEEN SMOKING BURDERN AND ONCOLOGIC OUTCOMES OF UPPER TRACT UROTHELIAL CARCINOMA: ANALYSIS OF THE ROBUUST COLLABORATION
Recommended Citation
Bhanvadia RR, Holland L, Popokh B, Taylor J, Margulis V, Sundaram CP, Derweesh IH, Abdollah F, Ferro M, Djaladat H, Autorino R, Simone G, Mehrazin R, Gonzalgo ML, Wu Z, Porpiglia F, Eun DD. ASSOCIATION BETWEEN SMOKING BURDERN AND ONCOLOGIC OUTCOMES OF UPPER TRACT UROTHELIAL CARCINOMA: ANALYSIS OF THE ROBUUST COLLABORATION. Urol Oncol 2024; 42:S25-S26.
Document Type
Conference Proceeding
Publication Date
3-1-2024
Publication Title
Urol Oncol
Abstract
Introduction: Most studies in urothelial cancer have examined smoking status (current, former, never), but often fail to quantify smoking burden/exposure, which has been shown to be prognostic in other malignancies. The impact of smoking burden on oncologic outcomes for upper tract urothelial carcinoma (UTUC) remains understudied with current literature providing mixed results.;Limitations of the;existing literature;include the lack;of patients who received neoadjuvant chemotherapy (NAC) and only a low proportion of patients receiving adjuvant therapy (AC). The relationship between smoking burden and pathologic downstaging after NAC in UTUC is largely unknown, and survival data has been mixed. We therefore performed a contemporary analysis of smoking burden;on oncologic outcomes in patients with UTUC undergoing radical nephroureterectomy (RNUx) utilizing a larrge;multicentered, multinational cohort (ROBUUST 2.0). Methods: We performed a retrospective analysis from a large multicentered cohort of 1,730 patients with UTUC across 17 institutions from 2005-2022. We excluded patients with incomplete smoking history, pathologic data, non-urothelial histology, and prior or concurrent cystectomy. All patients underwent RNUx. Smoking history included current smoking status, cigarettes per day (CPD), total pack-years (TPY), and cumulative smoking exposure. Based on prior studies, cumulative smoking exposure was stratified as light (≤19 CPD & ≤19 years smoking), or heavy (>20 CPD & >20 years smoking), with all other cases being moderate exposure. For analysis, light and moderate smoking exposure groups were combined.;Survival outcomes of cancer specific (CSS) and overall survival (OS) were assessed using the Kaplan-Meier method and multivariable competing risk regression to adjust for competing risk of non-cancer mortality from smoking exposure. A multivariable regression analysis was performed to examine odds of achieving pathologic down-staging;(
Volume
42
First Page
S25
Last Page
S26
