TEMPORAL TRENDS IN AGE AT PRESENTATION FOR PEYRONIE'S DISEASE PATIENTS: A 20-YEAR SINGLE-CENTER COHORT STUDY
Recommended Citation
Bertini A, Pozzi E, Belladelli F, Negri F, Corsini C, Raffo M, Malvestiti M, Oddo M, Birolini G, Matloob R, Boeri L, D'arma A, Abdollah F, Montorsi F, Salonia A. TEMPORAL TRENDS IN AGE AT PRESENTATION FOR PEYRONIE'S DISEASE PATIENTS: A 20-YEAR SINGLE-CENTER COHORT STUDY. J Sex Med 2025; 22(Supplement 2):1.
Document Type
Conference Proceeding
Publication Date
5-9-2025
Publication Title
J Sex Med
Abstract
Objectives: Peyronie’s disease (PD) is a common complaint even among young men, yet prevalence and risk factors of PD in these patients have been scantly analysed. We assessed sociodemographic and clinical characteristics of young men with new onset PD, highlighting changes over a 20-year period at a single tertiary referral centre. Methods: Data from 689 men presenting with PD at a single center were prospectively analysed. Comorbidities were scored with the Charlson Comorbidity Index (CCI). All patients completed the International Index of Erectile Function (IIEF) and Beck’s inventory for depression (BDI) at baseline. Patients were grouped into <40 vs. >40 years at first presentation. Univariable (UVA) Linear and Logistic regression models were fitted to explore changes in patterns of sociodemographic and clinical characteristics over a 19-yr period (2005-2024). Loess curve graphically displayed the association between age at first clinical visit and year of assessment. Results: Overall, median (IQR) age at presentation was 55 (44-62) years. 327 (47%) patients showed a CCI >2 and 33 (8.4%) patients reported at least one previous cardiovascular event. Of all, 144 (21%) men aged >40 at baseline. Younger patients had higher probability to be single persons (30% vs. 7.5%, p < 0.001) and active smoker (38% vs 20%, p < 0.001), reporting lower rates of CCI > 2 (4.2% vs. 59%, p < 0.001), arterial hypertension (2.5% vs. 45%, p < 0.001), cardiovascular events (0% vs. 10%, p = 0.003) and erectile dysfunction (ED) (50% vs. 64%, p = 0.014). Groups did not differ in median IIEF and BDI scores. At linear UVA, patients were younger (beta: -0.24, p = 0.04), with less comorbidities (beta: -0.03, p = 0.005), and lower IIEF-EF scores (beta: -0.33, p = 0.02) over the analyzed timeframe. At logistic UVA, patients evaluated for PD in recent years were more likely to be smokers (OR: 1.10, p < 0.001), to exercise more (OR: 1.06, p < 0.001) and report arterial hypertension (OR: 1.05, p = 0.02). Conclusions: Overall, one out of five patients seeking first medical help for PD was younger than 40 years, with a probability of assessing younger PD patients gradually increased over the last 20 years. Current findings confirm the severe impact of PD throughout ages.
Volume
22
Issue
Supplement 2
First Page
1
