Ovarian tumor microenvironment contributes to tumor progression and chemoresistance
Recommended Citation
Ponton-Almodovar A, Sanderson S, Rattan R, Bernard JJ, and Horibata S. Ovarian tumor microenvironment contributes to tumor progression and chemoresistance. Cancer Drug Resist 2024; 7:53.
Document Type
Article
Publication Date
12-2024
Publication Title
Cancer Drug Resist
Abstract
Ovarian cancer is one of the deadliest gynecologic cancers affecting the female reproductive tract. This is largely attributed to frequent recurrence and development of resistance to the platinum-based drugs cisplatin and carboplatin. One of the major contributing factors to increased cancer progression and resistance to chemotherapy is the tumor microenvironment (TME). Extracellular signaling from cells within the microenvironment heavily influences progression and drug resistance in ovarian cancer. This is frequently done through metabolic reprogramming, the process where cancer cells switch between biochemical pathways to increase their chances of survival and proliferation. Here, we focus on how crosstalk between components of the TME and the tumor promotes resistance to platinum-based chemotherapy. We highlight the role of cancer-associated fibroblasts, immune cells, adipocytes, and endothelial cells in ovarian tumor progression, invasion, metastasis, and chemoresistance. We also highlight recent advancements in targeting components of the TME as a novel therapeutic avenue to combat chemoresistance in ovarian cancer.
PubMed ID
39802952
Volume
7
First Page
53
Last Page
53
