A Matched Analysis on the Prognostic Impact of Race on Survival Endpoints of Women with Early-Stage Endometrial Cancer

Authors

Aharon Feldman, Henry Ford HealthFollow
Sadaf Chaugle, Henry Ford HealthFollow
Charlotte Burmeister, Henry Ford HealthFollow
Adnan Munkarah, Henry Ford HealthFollow
Mohamed A. Elshaikh, Henry Ford HealthFollow

Recommended Citation

Feldman A, Chaugle S, Burmeister C, Munkarah A, and Elshaikh MA. A matched analysis on the prognostic impact of race on survival endpoints of women with early-stage endometrial cancer. Gynecol Obstet Invest 2018; Epub ahead of print:1-7.

Document Type

Article

Publication Date

1-1-2019

Publication Title

Gynecologic and obstetric investigation

Abstract

OBJECTIVE: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis.

METHODS AND MATERIALS: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated.

RESULTS: A total of 758 patients were included. Body mass index and Age-Adjusted Charlson comorbidity index was significantly higher in AA compared to NAA women. There were no significant differences between the AA and NAA groups in regard to 5-year RFS (94 vs. 93%), DSS (96 vs. 98%) or 5-year OS (90 vs. 92%). On multivariate analysis of survival endpoints for the entire study cohort, it was found that race (AA vs. NAA) was not a significant predictor of RFS, DSS, or OS. Grade 3 tumors and the presence of lymphovascular space invasion (LVSI) were the only 2 independent predictors of RFS and DSS, while age-adjusted Charlson comorbidity score, grade 3, stage II and the presence of LVSI were independent predictors of shorter OS.

CONCLUSIONS: When matched based on the tumor stage, grade, adjuvant treatment, age, and year of surgery, our study suggests that there is no statistically significant difference in any survival endpoints between AA and NAA women with early-stage EC. Based on these data, disparities in outcome likely do not stem from uterine cancer-related causes. The increased comorbidity burden in AA women is likely a factor contributing to the racial disparity in endometrial cancer.

PubMed ID

30540995

ePublication

ePub ahead of print

Volume

84

Issue

3

First Page

283

Last Page

289