TREND IN CANNABIS USE DISORDER AMONG PATIENTS UNDERGOING ABDOMINAL HYSTERECTOMY

Document Type

Conference Proceeding

Publication Date

9-16-2025

Publication Title

Anat Rec

Abstract

While cannabis use has been linked to surgical complications, limited research has focused on its effect on hysterectomy-specific outcomes. This study examined temporal trends and demographic characteristics of patients with cannabis use disorder (CUD) undergoing total, benign hysterectomy and assessed its impact on postoperative clinical and economic outcomes. This retrospective cohort study used the National Inpatient Sample (NIS) database from 2016-2021 to identify patients undergoing benign, total hysterectomy. Patients were grouped into CUD and non-CUD cohorts, matched by age, indication, and comorbidities using the Elixhauser Comorbidity Index. Outcomes included postoperative clinical and economic outcomes and healthcare utilization. T-tests were used for continuous variables, and Rao- Scott Chi-Square tests were used for categorical variables. Patients undergoing non-abdominal hysterectomy (i.e. laparoscopic) or above age 40 were excluded. Among 557,365 hysterectomy patients, those with CUD were significantly younger (49.7 vs. 53.0 years, p<0.001) and had a longer average hospital stay (4.6 vs. 3.6 days, p=0.032). CUD was associated with increased resource utilization and differences in postoperative outcomes. CUD is associated with younger age at surgery and prolonged hospitalization following benign total hysterectomy. These findings underscore the need for improved risk stratification and tailored perioperative care for patients with substance use disorders. Limitations & Considerations: Limitations include use of administrative data, lack of outpatient and readmission data, and potential for recall and misclassification bias. Future studies should incorporate clinical validation and address residual confounding.

Volume

308

First Page

111

Last Page

112

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